Liverpool are also sweating on the fitness of striker Mohamed Salah, who picked up a groin injury on worldwide duty with Egypt while fellow forward Sadio Mane is a major doubt after having hand surgery.
Salah suffered a groin injury while playing for Egypt against eSwatini last Friday night and pulled out of the return game in the African...
The Reds saw 19 first-team players depart on global duty during this month's break, but four returned early after suffering fitness issues.
Salah and Van Dijk withdrew from their national teams over the worldwide break amid fitness concerns, but trained at Melwood on Thursday afternoon.
Liverpool head in to the weekend action sitting level on points with Manchester City and Chelsea at the top of the Premier League table so Klopp will want to at least maintain that status with another win over Huddersfield.
On defender Van Dijk, who was ruled out of Holland's friendly with Belgium with what Ronald Koeman described as "two broken ribs", Klopp added: "Football players play often with pain".
He said: "I have known Jurgen long enough, I know he loves to use smoke screens". 'Hopefully I won't give him one tomorrow'. Obviously, he knows that he needs to try and do a little more than he is doing right now but he's giving his all and I'm not anxious at all.
Information from Reuters was used in this story.