Mrs. Trump also visited schoolchildren and children at a hospital as crowds of people stood around her in awe of her elegance and grace.
Melania Trump then watched as health officials weighed babies in sacks hanging from a pulley as part of routine wellness checks.
There to receive her was Ghana's First Lady, Rebecca Akufo-Addo.
With the Africa visit, the first lady aims to take "Be Best" and its focus on opioid abuse and online behaviour to an worldwide audience.
She would also be making a donation to the facility.
A spokeswoman for Mrs. Trump said the first ladies exchanged gifts: a White House tray in a signed leather case for Akufo-Addo and Kente cloth and traditional artifacts for Mrs. Trump.
There's an overall sense of skepticism that exists around her trip and her motivations-and rightfully so.
Next up, she was headed off to a private tea with the First Lady of Ghana at the presidential palace.
On Monday, FLOTUS departed from Joint Base Andrews in Maryland for Ghana, the first stop on her week-long African tour -and she put her best, leopard print stiletto-clad foot forward. The first lady will also highlight the role Washington plays in helping each country, according to the U.S. Agency for International Development (USAID), which helped to coordinate the trip. The blankets, White House pool reports note, are branded with the "Be Best" slogan that Trump launched in May.