All three goals came in a frantic opening 20 minutes on Tyneside with Vertonghen and Alli heading goals for the north London team, who finished third last season. "We don't get caught up in what's going on around [us]".
Nine of Tottenham Hotspur's squad only returned to the training ground a few days before the Saturday clash at St James' Park due to their World Cup success.
Tottenham kick-off their 2018/19 campaign with a trip to St James' Park to take on Newcastle United at lunchtime.
"Everyone has been so excited about the prospect of playing in the new Tottenham Hotspur Stadium and I know all at the Club are very disappointed, but determined to clear this final hurdle", Mark Waller, NFL Executive Vice-President, International, said in a statement.
"At a time when Ronaldo's gone to Italy and top stars continue to flock to the likes of Real Madrid and Barcelona, we shouldn't be handing our clubs at home a disadvantage".
Their glee didn't last long, however, with Alli arriving at the back post to head in Aurier's deep cross for what proved to be the victor. The goalkeeper made a great save and I was happy with the technology.
However, just 149 seconds later, the hosts restored parity through Joselu. Newcastle allowed Alli a free run at the far post to send a precise header back across Dubravka into the far corner from Serge Aurier's inviting cross, which was whipped in from the right.
Spurs, whose starting 11 contained many players who were involved in the latter stages of the World Cup, later faded.
Diame was afforded room in the box to clatter a left-footed shot against the upright, while Alli should have done better at the other end when picked out by another delightful Eriksen ball.
Still, there's no question Newcastle look like a better team twelve months down the line. "You could feel the fans had belief that we could do something".
"We appreciate the support our partner the National Football League has shown since the extent of this issue became evident today", Tottenham chairman Daniel Levy said Monday.