Expect both Rahul and Karthik to feature in the second T20 with murmurs that opener Rohit Sharma could be given a rest.
Ireland will return to action in August when they host Afghanistan in three T20Is and three ODIs in August, with India now off to Old Trafford for Tuesday's first Twenty20 global against England, live on Sky Sports Cricket (channel 404) and Sky Sports Main Event (401) from 5pm.
Nevertheless, Raina provides a sixth bowling option as well.
The visitors eased to a 76-run victory in the first of the two-match series at Malahide on Wednesday. It could mean that Pandey eventually warms the bench, despite scoring 255 runs in 8 T20Is this year against South Africa, Sri Lanka and Bangladesh at an average of 85.
Wrist-spinners Yuzvendra Chahal and Kuldeep Yadav will operate in tandem at the expense of young and talented Washington Sundar as Kohli would want his wreckers-in-chief to get a taste of the conditions early in the tour.
O'Brien lasted just two balls while batting, however, as he became one of three Ireland players to register ducks - Kuldeep ending a sorry innings when he had Rankin stumped by Dinesh Karthik. Umesh Yadav who played well in IPL is expected to be in the Playing XI. Siddharth Kaul was in the Indian squad for the home ODIs against Sri Lanka in December, but was not picked ahead of Kumar-Bumrah. Kohli has stuck to his words and made as many as four changes in the playing eleven. It remains to be seen if the think tank will bench either Kumar or Bumrah against Ireland to give other pacers some much needed overs. Meanwhile, 31-year-old Punjab-born off-spinner Simranjit Singh will enjoy the spotlight of playing against his erstwhile nation.
Ireland captain Gary Wilson announced that top-order batsman William Porterfield returned in the place of wicketkeeper Stuart Poynter.