The 22-year-old winger enjoyed a brilliant season at Manchester City, earning PFA Young Player of the Year honours, but he won't be present in Russian Federation.
Germany have included 2014 World Cup-winning goalkeeper Manuel Neuer in their final squad for the 2018 tournament, even though he has only just returned from a long-term absence through injury.
The 22-year-old winger, who won the Premier League title with Manchester City and was voted young player of the year by the Professional Footballers' Association, didn't make the cut when Joachim Loew reduced his squad to 23 players.
There is a place in the squad, however, for goalkeeper Manuel Neuer, who returned after nine months injured in Germany's 2-1 friendly defeat against Austria on Saturday. Draxler, Reus and Muller are set. "Leroy has a huge talent", Low said at a press conference on Monday, per Metro.
Low explained: 'That was a very close decision between him and Julian Brandt, which was made in favor of Brandt'. He had not arrived in global matches yet.
He is still one of the most exciting young talents in European football, though, and City colleague Walker is amazed to learn that he will not be joining him in Russian Federation.
"There are certainly easier days in the life of a national team head coach than they day where I have to send four payers home", he added.
'It's as if you are stood at the check in desk for your flight to Moscow, but are then prevented from boarding'.
Germany are in Group F with Mexico, Sweden and South Korea, and play their first match on Sunday, 17 June.