As was expected, Benítez named an unchanged side for the game after his side's 2-1 victory away to Leicester City last weekend. Realistically, Arsenal already had no chance of making the top four and Wenger had been prioritising their Europa League campaign for several weeks.
Full-back Calum Chambers passed up an opportunity to restore the Gunners' lead six minutes before the break when unlike Lacazette, he could not stretch far enough to direct Mustafi's headed cross on goal.
Therefore, the game ended in yet another away loss for the Gunners, who have yet to even take a point away from home in the league in 2018, while the win all but means that Newcastle are safe from relegation this season.
"Their second goal sums up our away form this season - we made a number of mistakes which led to the goal". A run that incidentally ended with a victory at St. James Park almost 35 years ago.
The stage was set for Arsenal to kick on an dominate this match but they just didn't.
Their next away trip does not look too favourable for Wenger either, as they travel to Old Trafford to take on Mourinho's Manchester United.
It was Arsenal's 11th defeat of the season.
With Premier League clubs having voted to restrict VAR to cup competitions once more in 2017-18, Wenger thinks such incidents will continue to undermine matches.
Question marks were perhaps being raised of the Frenchman's capabilities in north London after the Gunners secured the signature of pace-merchant and perennial goalscorer Aubameyang, but he still remains the club's top-scorer.
That last tweet alludes to Arsenal's forthcoming Europa League semi final against Atletico Madrid. "Today we didn't play incredible football because we played an unbelievable team, but you have to manage how you play and compete for the win". For a second time in a week he was beaten by a run at the near post with Perez this time the benefactor.