More mistakes by Coates early in the second half created a pair of chances for Costa, but Patricio proved himself equal to the challenge on both occasions.
The Spain worldwide has since sat out LaLiga fixtures against Villarreal and Deportivo La Coruna but returned to training with the first-team squad earlier this week.
Antoine Griezmann bagged his 17th goal of 2018 to seal Atletico Madrid's 2-0 victory over Sporting in the first leg of the Europa League quarterfinals Thursday.
Ex-Chelsea striker Diego Costa took advantage of a defensive mistake seconds into the game to set Koke up.
Five minutes later Ramsey produced a bit of magic, volleying a pass from Ozil with his heel beyond goalkeeper Igor Akinfeev.
Diego Simeone's side saw out the game from there, and will expect to complete progress to the last four in next Thursday's second leg in the Portuguese capital - especially as Sporting's Fabio Coentrao and Bas Dost are now suspended.
"It's an important achievement to be runner-up in an important competition such as the Champions League but it's always better to be the champion, that's obvious".
"Indeed, we think we're even [with Sporting] for this qualifying round, Sporting have a great coach, a very capable man, the teams he's trained always did a good job". "We have to go there with the right focus and try to win the game".
The hosts led after eight minutes through captain Senad Lulic, but Valon Berisha equalised with a penalty.
Italy's Lazio ended Salzburg's 35-game unbeaten run stretching back to August after the Austrian side were undone by late goals from Anderson and Immobile.
RB Leipzig in a match with "Marseilles" for the first time in its short history has kept his goal intact, and the only goal, Timo Werner brought the Germans to the semifinals.