The Clarets have been the surprise package of the Premier League campaign and, with nine matches to go, they are the best of the rest outside the big six and have a chance of qualifying for Europe next season.
The defence could revert to the Liverpool line-up as Angelo Ogbonna is set to return following illness and James Collins could be back from a hamstring strain.
Burnley stopped the rot with last week's 2-1 home win over Everton, recovering from a goal down to claim their first Premier League victory in nearly three months. There have been two goals or less in six of Burnley's last seven away games and the same outcome in West Ham's last three home games. Barnes may be an unorthodox "number 10", however, he proved highly effective in this role last weekend and could provide real problems to West Ham's porous defence on Saturday. They have had two sticky games so they will be fired up for this one.
Chris Wood came on to set up Barnes' goal and the New Zealand worldwide added a brace of his own, each strike prompting additional ugly scenes, with some young children taking refuge on the Burnley bench to apparently escape unrest in the stands.
"We had just conceded a goal, we needed to get back into the game and find a way we could put Burnley under pressure".
Jordan Mansfield Mark Noble of West Ham United clashes with a pitch invader
"Up until the goal you wouldn't have thought that it would have been such a bad day", West Ham boss Moyes told BBC Sport. If people come on the pitch I can't imagine they're trying to be unsafe towards players.
If the West Ham manager needs to try to change things against Burnley then he can look to his bench, where available to bring on are Patrice Evra and Javier Hernandez, amongst others. He only signed a contract until the end of the season when he took over in November.
An FA investigation is underway while an emergency meeting of all London Stadium stakeholders has also been called after the West Ham owners David Sullivan and David Gold were forced to leave the game early for their own safety.