In the attacking department, veteran striker Zlatan Ibrahimovic is fit again and training, but Mourinho has ruled him out of contention for the game against Palace.
In front of them, Alexis Sanchez and Paul Pogba provided another line for Chelsea to try and breach, with the Chile worldwide often seen coming back to harry N'Golo Kante in the Chelsea engine room. The Portuguese manager receives criticism everyday for how he should run the club.
Former Manchester United defender Neville isn't impressed the Red Devils are so far behind Manchester City in the title race.
"If you ask me second or fourth I say by the financial point of view it doesn't make a difference, by the prestige point of view doesn't make a difference, you go to Champions League and the fourth doesn't even now have to play the last qualification". But the players kept an unbelievable attitude.
FW Alexis Sanchez, 5 - Quiet game from the Chilean. The Serbian has too often been left with too much to do with the effects clearly visible, now standing as the only outfield player to have started every league game this season.
Additionally, Romelu Lukaku is in great form right now.
Benteke cleared off the line from Matic, when it looked like United had got their equalizer. That being said, the Red Devils will be away from home and I expect Crystal Palace to fight hard.
Mourinho's issue this season has been mixing his penchant for structure with a number of players who are at their best when given licence to roam.
Palace are languishing in the relegation zone but will be determined to cause an upset and get the better of United. The midfielder is fast and technical, and he has a few tricks up his sleeve.
On Manchester United's end, the team will be quite depleted but most of their absences will be on the defensive end.
Having been second for most of the season, Jose will surely feel that anything less than second best would be considered a failure.