While all the debate in recent days has surrounded the role of Paul Pogba, United are also facing up to the prospect of losing Marouane Fellaini on a free transfer, with reports that he has agreed to move to Juventus. However, the Frenchman misses a huge match against a Premier League opponent in the FA Cup. Having been left out of the starting team (in favour of Scott McTominay) for United's win over Huddersfield, before being substituted off in the game against Newcastle, there were suggestions that the manager and player had fallen out.
Mourinho clarified that Pogba's preferred formation is 4-3-3 and playing as an "eight on the left", before urging the media to explain the game and not talk "b******t".
Although Mourinho insisted United will not treat the competition lightly.
If Michael Carrick fails to meet Mourinho's expectations, he has Jesse Lingard on the bench.
The former England star said: "Scotty has done great".
Pogba has made nine assists and scored three goals in 17 league appearances.
In doing so they would equal Arsenal's record for most FA Cup wins, which now stands at 13.
Huddersfield may prove themselves to be a tough opponent, but the Red Devils are looking for silverware.
Mourinho, whose second-placed side are a huge 16 points behind runaway Premier League leaders and local rivals Manchester City, believes Pogba's difficulties in overcoming hamstring and thigh injuries sustained in September have contributed to his struggles.
Manchester United will have several absentees ahead of this game.
"The important thing was that it didn't really matter because we won anyway". It could be the difference between silverware or not.
United sources say Pogba's "nose has been put out of joint" by the arrival of Alexis Sanchez from Arsenal last month. At first glance, it looks like a 4-3-3 formation, and a break from 4-2-3-1, which Mourinho has predominately used this season. But this time, these two sides will collide in the context of the FA Cup fifth round.
Video Assistant Refereeing has struck again and this time Juan Mata and Manchester United will feel the victims.