In that op-ed for the Times, Hayek alleged she was sexually harassed and berated by Harvey Weinstein for years while she tried to get her 2002 movie, Frida, made.
She has previously revealed in the NY times that Weinstein, who is accused of raping, sexually abusing and harassing dozens of actresses, once threatened to kill her and had pressured her into filming a nude sex scene with a female co-star.
"When the information about Harvey came out, I was ashamed I didn't say anything", Hayek told Oprah. "For years, he was my monster", she wrote in the essay, which details his increasing fury to Hayek rejecting his forceful advances.
She recounted in The Times that Weinstein threatened to kill her and pressured her into filming a nude sex scene with a female co-star. "I started crying when they asked and I ended up not doing it", the actor said.
She added: "I was ashamed I didn't say anything". I was supporting women for two decades but I couldn't do this...
When the headline-making investigation came out, Hayek remembers feeling a similar emotion, which ultimately convinced her to speak up about the abuse and harassment she says she endured while working with the former Hollywood producer. "I was pretending everything was OK, so I had been around Harvey and acting like everything was OK".
Addressing victims, she said, "I am a short, Mexican-Arab, angry woman. but I don't let that anger blur my vision". I went, 'Yes, no, yes, no, yes, no. "But I could not tell them then".
More than 75 women have now come forward to accuse the film maker of sexual harassment, abuse and rape - among them Angelina Jolie, Gwyneth Paltrow, Kate Beckinsale and Lupita Nyong'o.
The Frida star told Winfrey, 64, that she decided it was important to speak out because her pain was "so small" compared to other people's. "I thought of the shame". I thought of my daughter.
"There is a moment, and I feel like it's human, where I was like, there's no point for me to talk because it just happens to everyone, and then I felt that by itself, it was just my own little drama".
She added: 'It's important to take responsibility for the things we do to others, but we must stop apologizing for being attacked and we must move into a place where you can actually have a conversation.
Weinstein has denied all accusations of non-consensual sex but has not yet responded to a request for comment on Hayek's latest claims.
Now with women like Hayek speaking up, we like to think future generations will be more prepared to handle and shut down Weinstein-like abusers for good.
Salma Hayek and Oprah speak onstage during "Oprah's Super Soul Conversations" at The Apollo Theater on February 7, 2018 in NY.