Manchester City will return home to the Ethiad minus Gabriel Jesus and Kevin De Bruyne, both players were injured against Crystal Palace and it looks like both will miss several games.Jesus has been ruled out for a couple of months with knee ligament injuries.
And City's afternoon was further soured when Kevin De Bruyne was stretchered off with what appeared to be a serious looking injury immediately after the spot-kick following an ugly challenge by Palace substitute Jason Puncheon.
An animated conversation between De Bruyne and Leroy Sane confirmed the sense that City were growing increasingly uncomfortable and Sane - who was particularly ineffective - received a yellow card on the stroke of half-time when he kicked the ball away in frustration after being caught offside.
"We will recover one or two players who were unable to play today before the Southampton game, but after an effort like this you'd wish we could make the amount of changes that Manchester City feel they can always make when you look at the quality of the players they have who aren't playing".
Sergio Aguero will comeback into the side to replace Jesus and Sterling will look to continue his strong goal scoring form as the Citizens take on a struggling Watford team.
A 19th straight victory for City would have matched the record winning streak in Europe's top five leagues, set by Guardiola's Bayern Munich in the 2013-14 season. We knew that. The second half was better than the first.
Asked after the 0-0 draw with Crystal Palace whether he was planning a move for Sanchez, he explained: "He is a player from Arsenal and I think he is going to stay at Arsenal". There is one line but where you go beyond it, that is risky. "Protect them, that's all I can say", he said. In the 2003-04 season, Arsenal became the only club to get through an entire 38-game Premier League campaign without a defeat.
City came close to signing Sanchez on the final day of the summer transfer window.
Watford is the first test, with Marco Silva's team going into the game having had nearly 24 hours extra rest than City since their defeat against Swansea on Saturday.
City leads the Premier League by 14 points after 21 of 38 rounds.
Crystal Palace have only lost one of their last 10 Premier League games (W3 D6), having lost 13 of their 16 before this run.