Veteran Ortiz was pencilled in to challenge WBC heavyweight title holder Deontay Wilder on November 4, although an adverse finding was flagged earlier this week.
Wilder will make the defense at Barclays Center in Brooklyn against the same fighter he won the WBC version of the title from in January 2015. The results came back late September 28, and Ortiz's "A" sample tested positive for the banned diuretics chlorothiazide and hydrochlorothiazide, which are used to treat high blood pressure but also can be used as masking agents for performance-enhancing drug use.
Stiverne was scheduled to take on Dominic Breazeale on the undercard of his main event. Showtime will televise the contest. It was the only career non-knockout for Wilder, who is 38-0 with 37 KOs.
Ortiz was removed after failing a pre-fight drug test as part of the WBC's Clean Boxing Program.
31, of Tuscaloosa, Alabama, will face Stiverne for the second time.
"Despite all of these obstacles that are thrown in my path, it still will not stop me from reaching my ultimate goal, which is to be the undisputed heavyweight champion of the world".
"In the first fight, I broke my hand in the third round, and I still dominated". That was a lot of the reason why it went the distance.
"Deontay Wilder is a coward, he wanted to fight Luis Ortiz, because Ortiz is old and been inactive for a long time. This time it won't end well for him". "Wilder dodged a bullet in the first fight, but not this time".
But Wilder will still start the fight as an overwhelming favourite to record his sixth successful title defence.