On Saturday, Mkhitaryan was replaced shortly after the hour-mark by Jesse Lingard and United boss Jose Mourinho will now be hoping he does not pick up an injury while on worldwide duty with Armenia.
"That's our way of seeing [it]".
"I think Jose Mourinho will be annoyed they gave a goal away".
"That is exactly what we are looking to do and I think we've got the squad to do it".
"Without Zlatan, we can not rotate the striker, especially because Rashford is playing also in other positions", said Mourinho.
Mourinho also said that it was too early to assess United's title chances as they lie second in the league table, behind local rivals Manchester City on goal difference, after seven games.
In fact, Keane believes his old team "are back".
With the Red Devils facing a match less than every three days on average and mostly facing sterner opposition, their injuries will be felt, particularly those to important players like Pogba. "He was great at the end of last season and he has continued that now".
"I don't want to speak about this progress". Granted, certain scorelines may have been of a bigger margin, certain performances would likely have been better with the 24-year-old.
Mourinho, who hailed Lukaku's development since last working with the player during their time at Chelsea, said he must continue leading United's line until Ibrahimovic's return.
Lukaku will face his first big test of the campaign when United travel to Anfield to face Liverpool after the worldwide break on 14 October, but Keane insisted Lukaku should be judged at the end of the campaign.