This is the first slate of films to be announced for the fest.
Jolie's First They Killed My Father is set to hit the festival, a few months after the passion project about the Khmer Rouge genocide premiered in Siem Reap, Cambodia.
Other highly anticipated films to premiere at the festival include I, Tonya - which sees Margot Robbie star as disgraced United States figure skater Tonya Harding - and Stronger, starring Jake Gyllenhall in the true story about a man who lost his legs in the Boston Marathon bombing.
Organizers have announced Clooney's home-invasion comedy-drama "Suburbicon", written by the Coen brothers and starring Matt Damon and Julianne Moore, is among the titles to be screened at the festival.
Organisers of the Toronto International Film Festival (TIFF) - the largest in North America - will focus this year on female directors, screenwriters and actresses, in response to criticism that such events are too male-dominated. The festival will take place September 7th to 17th.
The Tragically Hip documentary "Long Time Running", directed by Canadians Jennifer Baichwal and Nicholas de Pencier, will have a gala opening. Harding was a two time Olympian and figure skating champion who ended up banned from the sport for her role in the attack against her chief American rival, Nancy Kerrigan, at the 1994 Winter Olympics.
In "Battle Of The Sexes", Steve Carell and Emma Stone star in a story inspired by the 1973 tennis match between Billie Jean King and Bobby Riggs. Paul Rudd can also be seen as Major League Baseball player turned WWII operative Moe Berg in Ben Lewin's adaptation of "The Catcher Was a Spy".
Mary Shelley, a biopic of the Frankenstein author starring Elle Fanning, Game Of Thrones star Maisie Williams and Downton Abbey's Joanne Froggatt, will receive its world premiere at the festival, as will The Mountain Between Us, starring Idris Elba and Kate Winslet. This is the new film of the tandem of film directors Eric Toledano and Olivier Nakache, to whom we owe the huge success of Intouchables in 2011.
Cinephiles have been wondering whether Quebec director Denis Villeneuve's much-anticipated "Blade Runner" sequel will be at the festival but it was not in the lineup announced on Tuesday.
"Hostiles", a frontier drama starring Rosamund Pike and Christian Bale, directed by Scott Cooper ("Black Mass").